The following is the medical terms and definitions used throughout the site.
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What is Amyloidosis?
A term for a collection of diseases that result in the abnormal deposition of beta-pleated
amyloid protein throughout the body. In animals, only reactive amyloidosis has been
described and its precursor protein is serum amyloid A protein. It has been demonstrated
conclusively that some Shar-Pei have an inherited form of amyloidosis. Amyloid AA composes
the fibrils in the amyloid deposits in the body which stain brick red with Congo Red
stain (CRS)(see Figure 2) and everything else pink. When examined by a pathologist using
a special microscope, they have a characteristic apple green color with birefringence
under polarized light (see Figure 3). In severe cases, the amorphous pink amyloid
substance may be obvious to the pathologist on microscopic exam even under normal stains
without CRS (as in Figure 1) but submitted tissues cannot be said to be negative for amyloidosis
unless the special stain is used.
Figure 1.
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Figure 2
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Figure 3
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How is Amyloid Made?
Any time that inflammation occurs, certain chemicals are produced and released into the
blood. These chemicals of inflammation are called the Acute Phase Reactant Proteins (APP).
After the inflammation has gone away, the APP are broken down by the body and eliminated.
Dogs (or people) with amyloidosis can't break these APP down into a form that can be
excreted by the body and instead turn it into serum Amyloid AA and dump it outside the
cells but still within the body
Why does the Amyloid make them sick?
- Amyloid is constantly deposited outside the cells. It builds up like a garbage
heap in an alley way until it starts to squeeze the adjacent cell walls.
- The compressed cells can't work properly. The damage or disease that results
depends on what kinds of body cells are most severely damaged or killed.
- Kidneys can't heal themselves by growing new kidney cells. If a kidney cell dies,
it is gone for good and can't be replaced. This is why the amyloid protein usually
causes kidney failure first
- Less commonly, the liver fails from amyloidosis.
Why Does Familial Shar-Pei Fever predispose these dogs to Amyloidosis?
Dogs with FSF have chronically elevated levels of the chemicals that raise the levels
of the APP - even when they are not having fevers. If the dog's body is overwhelmed
by too much APP or there is a problem with the elimination process, amyloidosis occurs.
Why do some Shar-Pei with FSF get Amyloidosis and others do not?
- We are speculating that it is probably due to variables in the degree of APP in
the dog's bloodstream - some dogs may have mild levels and others severely elevated
amounts which may overwhelm their ability to eliminate them entirely. In humans
with periodic fever disorders, it is believed that there may be a linked mutation
that prevents the normal elimination of the by-products the APP leading to amyloidosis
in some patients. I suspect both factors are important in the development of
amyloidosis in Shar-Pei.
- FSF and Amyloidosis are closely linked and FSF is a huge risk factor for developing
Amyloidosis. However, not every Shar-Pei with recurrent fevers from FSF will develop
Amyloidosis. FSF does NOT always lead to early death from amyloidosis and some patients
suffer recurrent fevers all their lives and are negative by CRS for amyloidosis at
12 yrs of age or older. These dogs are the exception, not the rule. These dogs
may be heterozygous for the disorder - carriers - and it has been observed repeatedly
that if bred to another similar carrier, their offspring will often manifest with
amyloidosis. We will be looking closely at this in our studies with Drs. Avery and
Kastner's laboratories.
- Dogs with the underlying disorder causing chronic elevations in the APP do not
always manifest a fever before presenting with signs of amyloidosis. This is observed
with the human periodic fever disorders as well.
- To put this in perspective, I have seen hundreds of Shar-Pei in the last 20 yrs die
of amyloidosis, confirmed by pathologic exam, in my own practice. I have had one case
of amyloidosis in an 11 yr old non-Shar-Pei dog. Amyloidosis in non-Shar-Pei dogs is
a very rare event and occurs in much older dogs...
- I have seen FSF episodes but not amyloidosis (as of this date) in Shar-pei mixed breed dogs
We would like to thank Dr. Linda Tintle, DVM for her definitions.
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